TrumpRx Unveiled; Novo Nordisk Reports Bad 2026 Guidance
TrumpRx was unveiled Thursday. The president negotiated deals with 16 of the 17 largest brand drug makers and part of the arrangement includes steep discounts on TrumpRx for self-pay Americans. The initial launch includes discounted products from AstraZeneca, Eli Lilly, EMD Serono, Novo Nordisk and Pfizer. Additional manufacturers that have signed agreements will have products added to the platform over time. Right now, 43 prescription drugs treating various different conditions at varying discounts are on the website. Medications for asthma, infertility and obesity are among those available. The savings range between 33 and 93 percent off the list price of the drugs.
Trump has been driving other changes as well, including deploying models for most-favored-nation (MFN) pricing in Medicaid and Medicare. The deals he struck already gained MFN in Medicaid and such pricing on new drugs that come to market.
Some criticize the initiative because it will not benefit some 85% of the population with prescription drug insurance coverage. But the president deserves credit for making huge headway on cash pay, the Medicaid MFN changes, the MFN models, and deeper discounts in the Medicare drug price negotiations. More needs to be done, especially for commercial insurance, but Trump has delivered real reforms here.
In other news, Danish firm Novo Nordisk, maker of GLP-1 weight-loss drugs Ozempic and Wegovy, reported full-year 2025 results of 10% sales growth and 6% operating margin growth. However, it said 2026 sales and operating profit growth would be negative 5% to 13%. It blamed competition, patent expiration and lower U.S. prices. Meanwhile, U.S. firm Eli Lilly, maker of Mounjaro and Zepbound reported good news and positive expectations for 2026. Novo is also suing Hims and Hers for readying to market a “knock off” pill with Wegovy ingredients.
It is hard to get too concerned about Novo. Its stunning success earlier drove its profits as well as much of the small Danish nation’s GDP growth for several years. And as Trump often notes, foreign drug firms like Novo have earned profit on the backs of Americans. Some 75% of all profits come from America for brand drug makers.
Further, after a court stayed implementation of a pilot program that would convert upfront discounts to retrospective rebates in the 340B program, the Department of Health and Human Services (HHS) has agreed to scrap the proposal and potentially restart the process.
Additional articles: https://www.fiercepharma.com/pharma/trumprx-governments-cash-pay-drug-purchasing-tool-primed-launch and https://thehill.com/homenews/administration/5725804-trump-launches-online-prescription-drug-platform-trumprx-what-to-know/ and https://www.modernhealthcare.com/politics-regulation/mh-hhs-340b-drug-pricing-program-rebate-model/ and https://finance.yahoo.com/news/novo-nordisk-q4-earnings-call-134858973.html?guccounter=1&guce_referrer=aHR0cHM6Ly93d3cuZ29vZ2xlLmNvbS8&guce_referrer_sig=AQAAAJzUe6HiQKz3okVpdso7A0yLeZAIPW1Ub2ostzrg7ZONyQ8z1KWrDGM859gWDHSx-g-178HChmqc40o8i1lMq0Z0f8O1tXErWp6qrflxRiOQ5GwC6iEyxQ2Yhd9fdz-o9EckMhY6Yljg3gA_7GDG6JdxppPhxUpCV_1324WzFyBd and https://thehill.com/policy/healthcare/5724285-white-house-trumprx-launch-most-favored-nation/
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https://www.beckershospitalreview.com/pharmacy/trumprx-launches-with-discounts-on-40-drugs-5-takeaways